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TargetMethionine Aminopeptidase Type 1 (MetAP1)
LigandBDBM50433376
Substrate/Competitorn/a
Meas. Tech.ChEMBL_957175
EC50 430±n/a nM
Citation Zhang, FBhat, SGabelli, SBChen, XMiller, MSNacev, BACheng, YLMeyers, DJTenney, KShim, JSCrews, PAmzel, LMMa, DLiu, JO Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells. J Med Chem56:3996-4016 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Methionine Aminopeptidase Type 1 (MetAP1)
Name:Methionine Aminopeptidase Type 1 (MetAP1)
Synonyms:MAP 1 | MetAP 1 | Peptidase M 1
Type:Enzyme
Mol. Mass.:43220.79
Organism:Homo sapiens (human)
Description:MetAP1 with an N-terminal six histidine tag was expressed in baculovirus infected sf9 cells.
Residue:386
Sequence:
MAAVETRVCETDGCSSEAKLQCPTCIKLGIQGSYFCSQECFKGSWATHKLLHKKAKDEKA
KREVSSWTVEGDINTDPWAGYRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQ
ALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCY
PSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGE
VDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLF
HTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHT
LLVTDTGCEILTRRLDSARPHFMSQF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50433376
n/a
NameBDBM50433376
Synonyms:CHEMBL2375627
TypeSmall organic molecule
Emp. Form.C28H29Cl2N5
Mol. Mass.506.469
SMILESCc1nc(nc(NC[C@@H](NCCCCc2ccccc2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1 |r|
Structure
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