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Target
Glucagon receptor
Ligand
BDBM50433576
Substrate
n/a
Meas. Tech.
ChEMBL_960258 (CHEMBL2382751)
Ki
1600±n/a nM
Citation
 Guzman-Perez, A; Pfefferkorn, JA; Lee, EC; Stevens, BD; Aspnes, GE; Bian, J; Didiuk, MT; Filipski, KJ; Moore, D; Perreault, C; Sammons, MF; Tu, M; Brown, J; Atkinson, K; Litchfield, J; Tan, B; Samas, B; Zavadoski, WJ; Salatto, CT; Treadway, J The design and synthesis of a potent glucagon receptor antagonist with favorable physicochemical and pharmacokinetic properties as a candidate for the treatment of type 2 diabetes mellitus. Bioorg Med Chem Lett 23:3051-8 (2013) [PubMed]  Article 
Target
Name:
Glucagon receptor
Synonyms:
GCGR | GL-R | GLR_HUMAN | Glucagon Receptor (GCGR) | Glucagon receptor (GlucR)
Type:
Enzyme
Mol. Mass.:
54026.92
Organism:
Homo sapiens (Human)
Description:
P47871
Residue:
477
Sequence:
MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
  
Inhibitor
Name:
BDBM50433576
Synonyms:
CHEMBL2381849
Type:
Small organic molecule
Emp. Form.:
C26H28F3N3O4
Mol. Mass.:
503.5134
SMILES:
CCC[C@@H](Oc1cc(C)c(c(C)c1)-n1cc(cn1)C(F)(F)F)c1ccc(cc1)C(=O)NCCC(O)=O |r|
Structure:
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