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Target
Glycogen [starch] synthase, muscle
Ligand
BDBM50433688
Substrate
n/a
Meas. Tech.
ChEMBL_959319 (CHEMBL2384006)
EC50
580±n/a nM
Citation
 Qian, Y; Bolin, D; Conde-Knape, K; Gillespie, P; Hayden, S; Huang, KS; Olivier, AR; Sato, T; Xiang, Q; Yun, W; Zhang, X Design and synthesis of 2-N-substituted indazolone derivatives as non-carboxylic acid glycogen synthase activators. Bioorg Med Chem Lett 23:2936-40 (2013) [PubMed]  Article 
Target
Name:
Glycogen [starch] synthase, muscle
Synonyms:
GYS | GYS1 | GYS1_HUMAN | Glycogen [starch] synthase, muscle | Glycogen synthase (GYS1) | Muscle glycogen synthase
Type:
Enzyme
Mol. Mass.:
83779.52
Organism:
Homo sapiens (Human)
Description:
P13807
Residue:
737
Sequence:
MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN
  
Inhibitor
Name:
BDBM50433688
Synonyms:
CHEMBL2381152
Type:
Small organic molecule
Emp. Form.:
C23H19F3N2O4
Mol. Mass.:
444.4032
SMILES:
OC[C@@H](O)Cn1[nH]c2c(COc3ccc(cc3)-c3cc(F)c(F)cc3F)cccc2c1=O |r|
Structure:
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