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Target
Nuclear receptor ROR-alpha
Ligand
BDBM50434244
Substrate
n/a
Meas. Tech.
ChEMBL_960948 (CHEMBL2388708)
EC50
8900±n/a nM
Citation
 Dubernet, M; Duguet, N; Colliandre, L; Berini, C; Helleboid, S; Bourotte, M; Daillet, M; Maingot, L; Daix, S; Delhomel, JF; Morin-Allory, L; Routier, S; Walczak, R Identification of New Nonsteroidal ROR? Ligands; Related Structure-Activity Relationships and Docking Studies. ACS Med Chem Lett 4:504-8 (2013) [PubMed]  Article 
Target
Name:
Nuclear receptor ROR-alpha
Synonyms:
NR1F1 | Nuclear receptor RZR-alpha | Nuclear receptor subfamily 1 group F member 1 | RAR-related orphan receptor A | RORA | RORA_HUMAN | RZRA | Retinoid-related orphan receptor-alpha
Type:
PROTEIN
Mol. Mass.:
58976.26
Organism:
Homo sapiens (Human)
Description:
ChEMBL_101591
Residue:
523
Sequence:
MESAPAAPDPAASEPGSSGADAAAGSRETPLNQESARKSEPPAPVRRQSYSSTSRGISVTKKTHTSQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSKADSAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG
  
Inhibitor
Name:
BDBM50434244
Synonyms:
CHEMBL2385908
Type:
Small organic molecule
Emp. Form.:
C22H24N2O5
Mol. Mass.:
396.4364
SMILES:
CCOC(=O)C1C(NC(=O)N=C1C)c1ccc(OCc2ccccc2)c(OC)c1 |c:10|
Structure:
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