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Target
5'-AMP-activated protein kinase subunit beta-1
Ligand
BDBM50434748
Substrate
n/a
Meas. Tech.
ChEMBL_961928 (CHEMBL2390519)
IC50
44±n/a nM
Citation
 Engers, DW; Frist, AY; Lindsley, CW; Hong, CC; Hopkins, CR Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe. Bioorg Med Chem Lett 23:3248-52 (2013) [PubMed]  Article 
Target
Name:
5'-AMP-activated protein kinase subunit beta-1
Synonyms:
5'-AMP-activated protein kinase subunit beta-1 | AAKB1_HUMAN | AMP-activated protein kinase alpha-2/beta-1/gamma-3 | AMPK | AMPK subunit beta-1 | AMPKb | PRKAB1
Type:
n/a
Mol. Mass.:
30380.94
Organism:
Homo sapiens (Human)
Description:
Q9Y478
Residue:
270
Sequence:
MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI
  
Inhibitor
Name:
BDBM50434748
Synonyms:
CHEMBL2385600
Type:
Small organic molecule
Emp. Form.:
C16H13N5O
Mol. Mass.:
291.3073
SMILES:
COc1ccc(cc1)-c1cnc2c(cnn2c1)-c1cn[nH]c1
Structure:
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