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Target
Ileal sodium/bile acid cotransporter
Ligand
BDBM50434850
Substrate
n/a
Meas. Tech.
ChEMBL_963355 (CHEMBL2388852)
IC50
0.200000±n/a nM
Citation
 Wu, Y; Aquino, CJ; Cowan, DJ; Anderson, DL; Ambroso, JL; Bishop, MJ; Boros, EE; Chen, L; Cunningham, A; Dobbins, RL; Feldman, PL; Harston, LT; Kaldor, IW; Klein, R; Liang, X; McIntyre, MS; Merrill, CL; Patterson, KM; Prescott, JS; Ray, JS; Roller, SG; Yao, X; Young, A; Yuen, J; Collins, JL Discovery of a highly potent, nonabsorbable apical sodium-dependent bile acid transporter inhibitor (GSK2330672) for treatment of type 2 diabetes. J Med Chem 56:5094-114 (2013) [PubMed]  Article 
Target
Name:
Ileal sodium/bile acid cotransporter
Synonyms:
ASBT | Apical sodium-dependent bile acid transporter | IBAT | ISBT | Ileal Na(+)/bile acid cotransporter | Ileal sodium-dependent bile acid transporter | NTCP2_RAT | Na(+)-dependent ileal bile acid transporter | Ntcp2 | Slc10a2 | Sodium/taurocholate-cotransporting polypeptide, ileal | Solute carrier family 10 member 2
Type:
PROTEIN
Mol. Mass.:
38020.22
Organism:
Rattus norvegicus
Description:
ChEMBL_104627
Residue:
348
Sequence:
MDNSSVCSPNATFCEGDSCLVTESNFNAILSTVMSTVLTILLAMVMFSMGCNVEINKFLGHIKRPWGIFVGFLCQFGIMPLTGFILSVASGILPVQAVVVLIMGCCPGGTGSNILAYWIDGDMDLSVSMTTCSTLLALGMMPLCLFIYTKMWVDSGTIVIPYDSIGISLVALVIPVSIGMFVNHKWPQKAKIILKIGSIAGAILIVLIAVVGGILYQSAWIIEPKLWIIGTIFPIAGYSLGFFLARLAGQPWYRCRTVALETGMQNTQLCSTIVQLSFSPEDLNLVFTFPLIYTVFQLVFAAIILGMYVTYKKCHGKNDAEFLEKTDNDMDPMPSFQETNKGFQPDEK
  
Inhibitor
Name:
BDBM50434850
Synonyms:
CHEMBL2387397
Type:
Small organic molecule
Emp. Form.:
C25H34N2O5S
Mol. Mass.:
474.613
SMILES:
CCCC[C@]1(CC)CS(=O)(=O)c2cc(CNCC(O)=O)c(OC)cc2[C@H](N1)c1ccccc1 |r|
Structure:
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