Target
Ileal sodium/bile acid cotransporter
Ligand
BDBM50134411
Substrate
n/a
Meas. Tech.
ChEMBL_963355 (CHEMBL2388852)
IC50
22±n/a nM
Citation
 Wu, YAquino, CJCowan, DJAnderson, DLAmbroso, JLBishop, MJBoros, EEChen, LCunningham, ADobbins, RLFeldman, PLHarston, LTKaldor, IWKlein, RLiang, XMcIntyre, MSMerrill, CLPatterson, KMPrescott, JSRay, JSRoller, SGYao, XYoung, AYuen, JCollins, JL Discovery of a highly potent, nonabsorbable apical sodium-dependent bile acid transporter inhibitor (GSK2330672) for treatment of type 2 diabetes. J Med Chem 56:5094-114 (2013) [PubMed]  Article 
Target
Name:
Ileal sodium/bile acid cotransporter
Synonyms:
ASBT | Apical sodium-dependent bile acid transporter | IBAT | ISBT | Ileal Na(+)/bile acid cotransporter | Ileal sodium-dependent bile acid transporter | NTCP2_RAT | Na(+)-dependent ileal bile acid transporter | Ntcp2 | Slc10a2 | Sodium/taurocholate-cotransporting polypeptide, ileal | Solute carrier family 10 member 2
Type:
PROTEIN
Mol. Mass.:
38020.22
Organism:
Rattus norvegicus
Description:
ChEMBL_104627
Residue:
348
Sequence:
MDNSSVCSPNATFCEGDSCLVTESNFNAILSTVMSTVLTILLAMVMFSMGCNVEINKFLGHIKRPWGIFVGFLCQFGIMPLTGFILSVASGILPVQAVVVLIMGCCPGGTGSNILAYWIDGDMDLSVSMTTCSTLLALGMMPLCLFIYTKMWVDSGTIVIPYDSIGISLVALVIPVSIGMFVNHKWPQKAKIILKIGSIAGAILIVLIAVVGGILYQSAWIIEPKLWIIGTIFPIAGYSLGFFLARLAGQPWYRCRTVALETGMQNTQLCSTIVQLSFSPEDLNLVFTFPLIYTVFQLVFAAIILGMYVTYKKCHGKNDAEFLEKTDNDMDPMPSFQETNKGFQPDEK
  
Inhibitor
Name:
BDBM50134411
Synonyms:
(7R,9R)-7-Butyl-7-ethyl-2,3-dimethoxy-9-phenyl-6,7,8,9-tetrahydro-5-thia-8-aza-benzocycloheptene 5,5-dioxide | CHEMBL332370
Type:
Small organic molecule
Emp. Form.:
C23H31NO4S
Mol. Mass.:
417.562
SMILES:
CCCC[C@]1(CC)CS(=O)(=O)c2cc(OC)c(OC)cc2[C@H](N1)c1ccccc1
Structure:
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