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Target
Casein kinase I isoform epsilon
Ligand
BDBM50435037
Substrate
n/a
Meas. Tech.
ChEMBL_964507 (CHEMBL2393652)
IC50
>100000±n/a nM
Citation
 Lo Monte, F; Kramer, T; Gu, J; Brodrecht, M; Pilakowski, J; Fuertes, A; Dominguez, JM; Plotkin, B; Eldar-Finkelman, H; Schmidt, B Structure-based optimization of oxadiazole-based GSK-3 inhibitors. Eur J Med Chem 61:26-40 (2013) [PubMed]  Article 
Target
Name:
Casein kinase I isoform epsilon
Synonyms:
Axin-1/Casein kinase I epsilon | CKI-epsilon | CKIe | CSNK1E | Casein kinase 1 epsilon (CK1Ɛ) | Casein kinase I epsilon | Casein kinase I isoform epsilon (CK1 epsilon) | Casein kinase I isoform epsilon (CK1E) | Casein kinase I isoform epsilon (CK1epsilon) | KC1E_HUMAN
Type:
Protein
Mol. Mass.:
47340.25
Organism:
Homo sapiens (Human)
Description:
P49674
Residue:
416
Sequence:
MELRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQGGVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGAARNPEDVDRERREHEREERMGQLRGSATRALPPGPPTGATANRLRSAAEPVASTPASRIQPAGNTSPRAISRVDRERKVSMRLHRGAPANVSSSDLTGRQEVSRIPASQTSVPFDHLGK
  
Inhibitor
Name:
BDBM50435037
Synonyms:
CHEMBL2391127
Type:
Small organic molecule
Emp. Form.:
C24H17N3O3S
Mol. Mass.:
427.475
SMILES:
N#Cc1ccc(cc1)-c1ccc(CSc2nnc(o2)-c2ccc3OCCOc3c2)cc1
Structure:
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