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TargetMethionine Aminopeptidase Type 1 (MetAP1)
LigandBDBM50435212
Substrate/Competitorn/a
Meas. Tech.ChEMBL_963503
EC50 270±n/a nM
Citation Zhang, PYang, XZhang, FGabelli, SBWang, RZhang, YBhat, SChen, XFurlani, MAmzel, LMLiu, JOMa, D Pyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1. Bioorg Med Chem21:2600-17 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Methionine Aminopeptidase Type 1 (MetAP1)
Name:Methionine Aminopeptidase Type 1 (MetAP1)
Synonyms:MAP 1 | MetAP 1 | Peptidase M 1
Type:Enzyme
Mol. Mass.:43220.79
Organism:Homo sapiens (human)
Description:MetAP1 with an N-terminal six histidine tag was expressed in baculovirus infected sf9 cells.
Residue:386
Sequence:
MAAVETRVCETDGCSSEAKLQCPTCIKLGIQGSYFCSQECFKGSWATHKLLHKKAKDEKA
KREVSSWTVEGDINTDPWAGYRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQ
ALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCY
PSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGE
VDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLF
HTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHT
LLVTDTGCEILTRRLDSARPHFMSQF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50435212
n/a
NameBDBM50435212
Synonyms:CHEMBL2392905
TypeSmall organic molecule
Emp. Form.C27H34ClN7O2
Mol. Mass.524.058
SMILESCOc1ccc(nc1)-c1nc(C)c(Cl)c(NC[C@H](NC(=O)CCCN2CCNCC2)c2ccccc2)n1 |r|
Structure
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