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Target
Glucose-dependent insulinotropic receptor
Ligand
BDBM50435652
Substrate
n/a
Meas. Tech.
ChEMBL_964819 (CHEMBL2395065)
EC50
13±n/a nM
Citation
 Zhang, JK; Li, AR; Yu, M; Wang, Y; Zhu, J; Kayser, F; Medina, JC; Siegler, K; Conn, M; Shan, B; Grillo, MP; Eksterowicz, J; Coward, P; Liu, JJ Discovery and optimization of arylsulfonyl 3-(pyridin-2-yloxy)anilines as novel GPR119 agonists. Bioorg Med Chem Lett 23:3609-13 (2013) [PubMed]  Article 
Target
Name:
Glucose-dependent insulinotropic receptor
Synonyms:
G-protein coupled receptor 119 (GPR119) | GP119_HUMAN | GPR119 | Glucose-dependent insulinotropic receptor
Type:
Protein
Mol. Mass.:
36901.49
Organism:
Homo sapiens (Human)
Description:
Q8TDV5
Residue:
335
Sequence:
MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
  
Inhibitor
Name:
BDBM50435652
Synonyms:
CHEMBL2391429
Type:
Small organic molecule
Emp. Form.:
C22H18ClN3O5S
Mol. Mass.:
471.913
SMILES:
CCOC(=O)c1cc(C)nc(Oc2cccc(NS(=O)(=O)c3ccc(Cl)cc3)c2)c1C#N
Structure:
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