Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 1
Ligand
BDBM50435666
Substrate
n/a
Meas. Tech.
ChEMBL_964990 (CHEMBL2396023)
IC50
1.9±n/a nM
Citation
 Hossain, N; Ivanova, S; Bergare, J; Mensonides-Harsema, M; Cooper, ME Design, synthesis and structure activity relationships of spirocyclic compounds as potent CCR1 antagonists. Bioorg Med Chem Lett 23:3500-4 (2013) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 1
Synonyms:
C-C CKR-1 | C-C chemokine receptor type 1 (CCR1) | CC-CKR-1 | CCR-1 | CCR1 | CCR1_HUMAN | CD_antigen=CD191 | CMKBR1 | CMKR1 | HM145 | LD78 receptor | MIP-1alpha-R | Macrophage inflammatory protein 1-alpha receptor | RANTES-R | SCYAR1
Type:
Enzyme
Mol. Mass.:
41180.69
Organism:
Homo sapiens (Human)
Description:
P32246
Residue:
355
Sequence:
METPNTTEDYDTTTEFDYGDATPCQKVNERAFGAQLLPPLYSLVFVIGLVGNILVVLVLVQYKRLKNMTSIYLLNLAISDLLFLFTLPFWIDYKLKDDWVFGDAMCKILSGFYYTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIIIWALAILASMPGLYFSKTQWEFTHHTCSLHFPHESLREWKLFQALKLNLFGLVLPLLVMIICYTGIIKILLRRPNEKKSKAVRLIFVIMIIFFLFWTPYNLTILISVFQDFLFTHECEQSRHLDLAVQVTEVIAYTHCCVNPVIYAFVGERFRKYLRQLFHRRVAVHLVKWLPFLSVDRLERVSSTSPSTGEHELSAGF
  
Inhibitor
Name:
BDBM50435666
Synonyms:
CHEMBL2391804
Type:
Small organic molecule
Emp. Form.:
C26H31ClN2O6
Mol. Mass.:
502.987
SMILES:
O[C@H](COc1cc(O)ccc1C(=O)N1CC[C@H](O)C1)CN1CCC2(Cc3cc(Cl)ccc3O2)CC1 |r|
Structure:
Search PDB for entries with ligand similarity: