Reaction Details Report a problem with these data
Target
Presenilin-1
Ligand
BDBM50436208
Substrate
n/a
Meas. Tech.
ChEMBL_966384 (CHEMBL2398821)
EC50
>50000±n/a nM
Citation
 Naumann, EC; Göring, S; Ogorek, I; Weggen, S; Schmidt, B Membrane anchoring¿-secretase modulators with terpene-derived moieties. Bioorg Med Chem Lett 23:3852-6 (2013) [PubMed]  Article 
Target
Name:
Presenilin-1
Synonyms:
3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSN1_HUMAN | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182
Type:
n/a
Mol. Mass.:
52657.13
Organism:
Homo sapiens (Human)
Description:
P49768
Residue:
467
Sequence:
MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSRQVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAEGDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAAVQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
  
Inhibitor
Name:
BDBM50436208
Synonyms:
CHEMBL2398572
Type:
Small organic molecule
Emp. Form.:
C35H50ClNO2
Mol. Mass.:
552.23
SMILES:
CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC\C(C)=C\Cn1c2ccc(Cl)cc2c2ccc(cc12)C(C)C(O)=O |r|
Structure:
Search PDB for entries with ligand similarity: