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TargetAcyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2)
LigandBDBM50436339
Substrate/Competitorn/a
Meas. Tech.ChEMBL_966605
IC50 14±n/a nM
Citation Ohtawa, MYamazaki, HOhte, SMatsuda, DOhshiro, TRudel, LLOmura, STomoda, HNagamitsu, T Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 3. Bioorg Med Chem Lett23:3798-801 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2)
Name:Acyl coenzyme A:cholesterol acyltransferase 2
Synonyms:ACAT-2 | Acetyl-CoA acetyltransferase, cytosolic | Acetyl-CoA transferase-like protein | Acyl coenzyme A:cholesterol acyltransferase 2 | Cholesterol acyltransferase 2 | Cytosolic acetoacetyl-CoA thiolase | Sterol O-acyltransferase 2
Type:Enzyme
Mol. Mass.:59912.75
Organism:Homo sapiens (Human)
Description:O75908
Residue:522
Sequence:
MEPGGARLRLQRTEGLGGERERQPCGDGNTETHRAPDLVQWTRHMEAVKAQLLEQAQGQL
RELLDRAMREAIQSYPSQDKPLPPPPPGSLSRTQEPSLGKQKVFIIRKSLLDELMEVQHF
RTIYHMFIAGLCVFIISTLAIDFIDEGRLLLEFDLLIFSFGQLPLALVTWVPMFLSTLLA
PYQALRLWARGTWTQATGLGCALLAAHAVVLCALPVHVAVEHQLPPASRCVLVFEQVRFL
MKSYSFLREAVPGTLRARRGEGIQAPSFSSYLYFLFCPTLIYRETYPRTPYVRWNYVAKN
FAQALGCVLYACFILGRLCVPVFANMSREPFSTRALVLSILHATLPGIFMLLLIFFAFLH
CWLNAFAEMLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLRLLGARARG
VAMLGVFLVSAVAHEYIFCFVLGFFYPVMLILFLVIGGMLNFMMHDQRTGPAWNVLMWTM
LFLGQGIQVSLYCQEWYARRHCPLPQATFWGLVTPRSWSCHT
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50436339
NameBDBM50436339
Synonyms:CHEMBL2396678
TypeSmall organic molecule
Emp. Form.C40H41NO9
Mol. Mass.679.7548
SMILESCOc1ccc(cc1)C(=O)O[C@H]1C[C@H]2[C@]3(C)CO[C@H](O[C@H]3CC[C@]2(C)[C@H]2[C@@H](O)c3c(O[C@]12C)cc(oc3=O)-c1cccnc1)c1ccccc1 |r|
Structure
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