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Target
Sterol O-acyltransferase 2
Ligand
BDBM50436344
Substrate
n/a
Meas. Tech.
ChEMBL_966605 (CHEMBL2399639)
IC50
6.0±n/a nM
Citation
 Ohtawa, M; Yamazaki, H; Ohte, S; Matsuda, D; Ohshiro, T; Rudel, LL; Omura, S; Tomoda, H; Nagamitsu, T Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 3. Bioorg Med Chem Lett 23:3798-801 (2013) [PubMed]  Article 
Target
Name:
Sterol O-acyltransferase 2
Synonyms:
ACACT2 | ACAT-2 | ACAT2 | Acetyl-CoA acetyltransferase, cytosolic | Acetyl-CoA transferase-like protein | Acyl coenzyme A:cholesterol acyltransferase 2 | Cholesterol acyltransferase 2 | Cytosolic acetoacetyl-CoA thiolase | SOAT2 | SOAT2_HUMAN
Type:
Enzyme
Mol. Mass.:
59912.75
Organism:
Homo sapiens (Human)
Description:
O75908
Residue:
522
Sequence:
MEPGGARLRLQRTEGLGGERERQPCGDGNTETHRAPDLVQWTRHMEAVKAQLLEQAQGQLRELLDRAMREAIQSYPSQDKPLPPPPPGSLSRTQEPSLGKQKVFIIRKSLLDELMEVQHFRTIYHMFIAGLCVFIISTLAIDFIDEGRLLLEFDLLIFSFGQLPLALVTWVPMFLSTLLAPYQALRLWARGTWTQATGLGCALLAAHAVVLCALPVHVAVEHQLPPASRCVLVFEQVRFLMKSYSFLREAVPGTLRARRGEGIQAPSFSSYLYFLFCPTLIYRETYPRTPYVRWNYVAKNFAQALGCVLYACFILGRLCVPVFANMSREPFSTRALVLSILHATLPGIFMLLLIFFAFLHCWLNAFAEMLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLRLLGARARGVAMLGVFLVSAVAHEYIFCFVLGFFYPVMLILFLVIGGMLNFMMHDQRTGPAWNVLMWTMLFLGQGIQVSLYCQEWYARRHCPLPQATFWGLVTPRSWSCHT
  
Inhibitor
Name:
BDBM50436344
Synonyms:
CHEMBL2398815
Type:
Small organic molecule
Emp. Form.:
C40H38N2O8
Mol. Mass.:
674.7383
SMILES:
C[C@]12CC[C@@H]3O[C@@H](OC[C@@]3(C)[C@@H]1C[C@H](OC(=O)c1ccc(cc1)C#N)[C@@]1(C)Oc3cc(oc(=O)c3[C@H](O)[C@H]21)-c1cccnc1)c1ccccc1 |r|
Structure:
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