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Target
5'-AMP-activated protein kinase catalytic subunit alpha-2
Ligand
BDBM50436624
Substrate
n/a
Meas. Tech.
ChEMBL_967438 (CHEMBL2401228)
EC50
61500±n/a nM
Citation
 Meltzer-Mats, E; Babai-Shani, G; Pasternak, L; Uritsky, N; Getter, T; Viskind, O; Eckel, J; Cerasi, E; Senderowitz, H; Sasson, S; Gruzman, A Synthesis and mechanism of hypoglycemic activity of benzothiazole derivatives. J Med Chem 56:5335-50 (2014) [PubMed]  Article 
Target
Name:
5'-AMP-activated protein kinase catalytic subunit alpha-2
Synonyms:
AAPK2_RAT | AMP-activated protein kinase, alpha-2 subunit | Ampk | Ampk2 | Prkaa2
Type:
PROTEIN
Mol. Mass.:
62268.49
Organism:
Rattus norvegicus
Description:
ChEMBL_967438
Residue:
552
Sequence:
MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEVEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAQMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSIATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPTGSFMDDMAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSVDSSTAENHSLSGSLTGSLTGSTLSSASPRLGSHTMDFFEMCASLITALAR
  
Inhibitor
Name:
BDBM50436624
Synonyms:
CHEMBL1522339
Type:
Small organic molecule
Emp. Form.:
C5H8N2OS
Mol. Mass.:
144.195
SMILES:
CCc1sc(N)nc1O
Structure:
Search PDB for entries with ligand similarity: