Target
Bcl-2-like protein 1
Ligand
BDBM50436641
Substrate
n/a
Meas. Tech.
ChEMBL_967619 (CHEMBL2399239)
IC50
76000±n/a nM
Citation
 Sleebs, BEKersten, WJKulasegaram, SNikolakopoulos, GHatzis, EMoss, RMParisot, JPYang, HCzabotar, PEFairlie, WDLee, EFAdams, JMChen, Lvan Delft, MFLowes, KNWei, AHuang, DCColman, PMStreet, IPBaell, JBWatson, KLessene, G Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL. J Med Chem 56:5514-40 (2014) [PubMed]  Article 
Target
Name:
Bcl-2-like protein 1
Synonyms:
Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD)
Type:
Mitochondrion membrane; Single-pass membrane protein
Mol. Mass.:
26039.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
  
Inhibitor
Name:
BDBM50436641
Synonyms:
CHEMBL2398295
Type:
Small organic molecule
Emp. Form.:
C20H14ClN3O3S
Mol. Mass.:
411.861
SMILES:
CC(N=Nc1nc2ccccc2s1)c1ccc(o1)-c1cc(ccc1Cl)C(O)=O |w:3.3|
Structure:
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