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TargetBcl-xL/BAK
LigandBDBM50436643
Substrate/Competitorn/a
Meas. Tech.ChEMBL_967613
Kd 9000±n/a nM
Citation Sleebs, BEKersten, WJKulasegaram, SNikolakopoulos, GHatzis, EMoss, RMParisot, JPYang, HCzabotar, PEFairlie, WDLee, EFAdams, JMChen, Lvan Delft, MFLowes, KNWei, AHuang, DCColman, PMStreet, IPBaell, JBWatson, KLessene, G Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL. J Med Chem56:5514-40 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Bcl-xL/BAK
Name:Bcl-xL/BAK
Synonyms:Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | BCL2-like 1 isoform 1 | Bcl-2-like protein 1 | Bcl-2-like protein 1 (Bcl-XL) | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD)
Type:Mitochondrion membrane; Single-pass membrane protein
Mol. Mass.:26039.60
Organism:Homo sapiens
Description:n/a
Residue:233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLA
DSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAY
QSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEP
WIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
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  Blast E-value cutoff:
BDBM50436643
NameBDBM50436643
Synonyms:3-(5-(1-(2-(Benzo[d]thiazol-2-yl)hydrazono)ethyl)furan-2-yl)-benzoic acid (Compound 1b) | CHEMBL2398292
TypeSmall organic molecule
Emp. Form.C20H15N3O3S
Mol. Mass.377.416
SMILESCC(N=Nc1nc2ccccc2s1)c1ccc(o1)-c1cccc(c1)C(O)=O |w:3.3|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a