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TargetBcl-xL/BAK
LigandBDBM50181876
Substrate/Competitorn/a
Meas. Tech.ChEMBL_967612
Kd 1900±n/a nM
Citation Sleebs, BEKersten, WJKulasegaram, SNikolakopoulos, GHatzis, EMoss, RMParisot, JPYang, HCzabotar, PEFairlie, WDLee, EFAdams, JMChen, Lvan Delft, MFLowes, KNWei, AHuang, DCColman, PMStreet, IPBaell, JBWatson, KLessene, G Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL. J Med Chem56:5514-40 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Bcl-xL/BAK
Name:Bcl-xL/BAK
Synonyms:Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | BCL2-like 1 isoform 1 | Bcl-2-like protein 1 | Bcl-2-like protein 1 (Bcl-XL) | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD)
Type:Mitochondrion membrane; Single-pass membrane protein
Mol. Mass.:26039.60
Organism:Homo sapiens
Description:n/a
Residue:233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLA
DSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAY
QSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEP
WIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50181876
NameBDBM50181876
Synonyms:CHEMBL371861 | N-(4'-fluoro-biphenyl-4-carbonyl)-3-nitro-4-(2-phenylsulfanyl-ethylamino)-benzenesulfonamide | N-[(4'-FLUORO-1,1'-BIPHENYL-4-YL)CARBONYL]-3-NITRO-4-{[2-(PHENYLSULFANYL)ETHYL]AMINO}BENZENESULFONAMIDE
TypeSmall organic molecule
Emp. Form.C27H22FN3O5S2
Mol. Mass.551.609
SMILES[O-][N+](=O)c1cc(ccc1NCCSc1ccccc1)S(=O)(=O)NC(=O)c1ccc(cc1)-c1ccc(F)cc1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a