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TargetBcl-2-like protein 1
LigandBDBM50436648
Substrate/Competitorn/a
Meas. Tech.ChEMBL_967617
IC50 140±n/a nM
Citation Sleebs, BEKersten, WJKulasegaram, SNikolakopoulos, GHatzis, EMoss, RMParisot, JPYang, HCzabotar, PEFairlie, WDLee, EFAdams, JMChen, Lvan Delft, MFLowes, KNWei, AHuang, DCColman, PMStreet, IPBaell, JBWatson, KLessene, G Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL. J Med Chem56:5514-40 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Bcl-2-like protein 1
Name:Bcl-2-like protein 1
Synonyms:Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | BCL2-like 1 isoform 1 | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD)
Type:Mitochondrion membrane; Single-pass membrane protein
Mol. Mass.:26039.60
Organism:Homo sapiens (Human)
Description:n/a
Residue:233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLA
DSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAY
QSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEP
WIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50436648
NameBDBM50436648
Synonyms:CHEMBL2398286
TypeSmall organic molecule
Emp. Form.C21H16N4O2S
Mol. Mass.388.442
SMILESCC(N=Nc1nc2ccccc2s1)c1cccc(c1)-c1cccc(n1)C(O)=O |w:3.3|
Structure
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n/a