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Target
Major prion protein
Ligand
BDBM50437268
Substrate
n/a
Meas. Tech.
ChEMBL_972294 (CHEMBL2411805)
EC50
520±n/a nM
Citation
 Li, Z; Rao, S; Gever, JR; Widjaja, K; Prusiner, SB; Silber, BM Optimization of Arylamides as Novel, Potent and Brain-penetrant Antiprion Lead Compounds. ACS Med Chem Lett 4:647-650 (2013) [PubMed]  Article 
Target
Name:
Major prion protein
Synonyms:
CD_antigen=CD230 | PRIO_SHEEP | PRNP | PRP | SIP
Type:
PROTEIN
Mol. Mass.:
27930.26
Organism:
Ovis aries
Description:
ChEMBL_107628
Residue:
256
Sequence:
MVKSHIGSWILVLFVAMWSDVGLCKKRPKPGGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGSHSQWNKPSKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGNDYEDRYYRENMYRYPNQVYYRPVDRYSNQNNFVHDCVNITVKQHTVTTTTKGENFTETDIKIMERVVEQMCITQYQRESQAYYQRGASVILFSSPPVILLISFLIFLIVG
  
Inhibitor
Name:
BDBM50437268
Synonyms:
CHEMBL2407269
Type:
Small organic molecule
Emp. Form.:
C24H25N3O
Mol. Mass.:
371.4748
SMILES:
CN1CCN(CC1)c1ccc(NC(=O)c2ccc(cc2)-c2ccccc2)cc1
Structure:
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