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Target
Methionine aminopeptidase 1
Ligand
BDBM76305
Substrate
n/a
Meas. Tech.
ChEMBL_972464 (CHEMBL2412834)
IC50
12900±n/a nM
Citation
 Wangtrakuldee, P; Byrd, MS; Campos, CG; Henderson, MW; Zhang, Z; Clare, M; Masoudi, A; Myler, PJ; Horn, JR; Cotter, PA; Hagen, TJ Discovery of Inhibitors of ACS Med Chem Lett 4:699-703 (2013) [PubMed]  Article 
Target
Name:
Methionine aminopeptidase 1
Synonyms:
Aminopeptidase | KIAA0094 | MAP 1 | MAP11_HUMAN | METAP1 | MetAP 1 | Methionine Aminopeptidase Type 1 (MetAP1) | Peptidase M 1
Type:
Enzyme
Mol. Mass.:
43220.79
Organism:
Homo sapiens (Human)
Description:
MetAP1 with an N-terminal six histidine tag was expressed in baculovirus infected sf9 cells.
Residue:
386
Sequence:
MAAVETRVCETDGCSSEAKLQCPTCIKLGIQGSYFCSQECFKGSWATHKLLHKKAKDEKAKREVSSWTVEGDINTDPWAGYRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMSQF
  
Inhibitor
Name:
BDBM76305
Synonyms:
5-chloranylquinolin-8-ol | 5-chloro-8-quinolinol | 5-chloroquinolin-8-ol | MLS002695956 | SMR000274338 | cid_2817
Type:
Small organic molecule
Emp. Form.:
C9H6ClNO
Mol. Mass.:
179.603
SMILES:
Oc1ccc(Cl)c2cccnc12
Structure:
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