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Target
Dual specificity tyrosine-phosphorylation-regulated kinase 3
Ligand
BDBM50437434
Substrate
n/a
Meas. Tech.
ChEMBL_972720 (CHEMBL2410929)
IC50
70±n/a nM
Citation
 Dowling, JE; Alimzhanov, M; Bao, L; Block, MH; Chuaqui, C; Cooke, EL; Denz, CR; Hird, A; Huang, S; Larsen, NA; Peng, B; Pontz, TW; Rivard-Costa, C; Saeh, JC; Thakur, K; Ye, Q; Zhang, T; Lyne, PD Structure and Property Based Design of Pyrazolo[1,5-a]pyrimidine Inhibitors of CK2 Kinase with Activity in Vivo. ACS Med Chem Lett 4:800-5 (2013) [PubMed]  Article 
Target
Name:
Dual specificity tyrosine-phosphorylation-regulated kinase 3
Synonyms:
DYRK3 | DYRK3_HUMAN | Dual-specificity tyrosine-phosphorylation regulated kinase 3
Type:
PROTEIN
Mol. Mass.:
65747.26
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1508026
Residue:
588
Sequence:
MGGTARGPGRKDAGPPGAGLPPQQRRLGDGVYDTFMMIDETKCPPCSNVLCNPSEPPPPRRLNMTTEQFTGDHTQHFLDGGEMKVEQLFQEFGNRKSNTIQSDGISDSEKCSPTVSQGKSSDCLNTVKSNSSSKAPKVVPLTPEQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPASAFQGLGSKLPPVVGIANKLKANLMSETNGSIPLCSVLPKLIS
  
Inhibitor
Name:
BDBM50437434
Synonyms:
CHEMBL2409175
Type:
Small organic molecule
Emp. Form.:
C19H19N7O
Mol. Mass.:
361.4005
SMILES:
CC(=O)Nc1cc(Nc2cc(NC3CC3)n3ncc(C#N)c3n2)ccc1C
Structure:
Search PDB for entries with ligand similarity: