| Reaction Details |
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 | Report a problem with these data |
| Target | Leukocyte elastase |
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| Ligand | BDBM50437999 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_972954 |
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| IC50 | 15±n/a nM |
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| Citation |  Crocetti, L; Schepetkin, IA; Cilibrizzi, A; Graziano, A; Vergelli, C; Giomi, D; Khlebnikov, AI; Quinn, MT; Giovannoni, MP Optimization of N-benzoylindazole derivatives as inhibitors of human neutrophil elastase. J Med Chem56:6259-72 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Leukocyte elastase |
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| Name: | Leukocyte elastase |
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| Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
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| Type: | Enzyme |
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| Mol. Mass.: | 28532.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08246 |
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| Residue: | 267 |
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| Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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| BDBM50437999 |
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| Name | BDBM50437999 |
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| Synonyms: | CHEMBL2409452 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H13N3O5 |
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| Mol. Mass. | 339.3022 |
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| SMILES | COC(=O)c1nn(C(=O)c2cccc(C)c2)c2ccc(cc12)[N+]([O-])=O |
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| Structure | 
|
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| n/a |
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