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Target
Neutrophil elastase
Ligand
BDBM50437999
Substrate
n/a
Meas. Tech.
ChEMBL_972954 (CHEMBL2412035)
IC50
15±n/a nM
Citation
 Crocetti, L; Schepetkin, IA; Cilibrizzi, A; Graziano, A; Vergelli, C; Giomi, D; Khlebnikov, AI; Quinn, MT; Giovannoni, MP Optimization of N-benzoylindazole derivatives as inhibitors of human neutrophil elastase. J Med Chem 56:6259-72 (2013) [PubMed]  Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50437999
Synonyms:
CHEMBL2409452
Type:
Small organic molecule
Emp. Form.:
C17H13N3O5
Mol. Mass.:
339.3022
SMILES:
COC(=O)c1nn(C(=O)c2cccc(C)c2)c2ccc(cc12)[N+]([O-])=O
Structure:
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