Target
Cathepsin D
Ligand
BDBM50438360
Substrate
n/a
Meas. Tech.
ChEMBL_973546 (CHEMBL2410948)
IC50
6.0±n/a nM
Citation
 Ng, RASun, MBowers, SHom, RKProbst, GDJohn, VFang, LYMaillard, MGailunas, ABrogley, LNeitz, RJTung, JSPleiss, MAKonradi, AWSham, HLDappen, MSAdler, MYao, NZmolek, WNakamura, DQuinn, KPSauer, JMBova, MPRuslim, LArtis, DRYednock, TA Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: prime side chromane-containing inhibitors. Bioorg Med Chem Lett 23:4674-9 (2013) [PubMed]  Article 
Target
Name:
Cathepsin D
Synonyms:
CATD_HUMAN | CPSD | CTSD | Cathepsin D [Precursor] | Cathepsin D heavy chain | Cathepsin D light chain | Cathepsin D precursor
Type:
Enzyme
Mol. Mass.:
44551.72
Organism:
Homo sapiens (Human)
Description:
Human proCathepsin D (SwissProt accession number P07339) was expressed in Sf9 cells, purified, and autoactivated.
Residue:
412
Sequence:
MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL
  
Inhibitor
Name:
BDBM50438360
Synonyms:
CHEMBL2408755
Type:
Small organic molecule
Emp. Form.:
C28H36F2N2O3
Mol. Mass.:
486.5938
SMILES:
CC(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CN[C@H]1CC2(CC2)Oc2ccc(CC(C)(C)C)cc12 |r|
Structure:
Search PDB for entries with ligand similarity: