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TargetHeme Oxygenase 1 (HO-1)
LigandBDBM50438664
Substrate/Competitorn/a
Meas. Tech.ChEMBL_976175
IC50>100000±n/a nM
Citation Salerno, LPittalà, VRomeo, GModica, MNSiracusa, MADi Giacomo, CAcquaviva, RBarbagallo, ITibullo, DSorrenti, V Evaluation of novel aryloxyalkyl derivatives of imidazole and 1,2,4-triazole as heme oxygenase-1 (HO-1) inhibitors and their antitumor properties. Bioorg Med Chem21:5145-53 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Heme Oxygenase 1 (HO-1)
Name:Heme oxygenase 1
Synonyms:HSP32
Type:Enzyme
Mol. Mass.:33005.15
Organism:Rattus norvegicus (rat)
Description:HO-1 obtained from rat spleen was used in enzyme assays.
Residue:289
Sequence:
MERPQLDSMSQDLSEALKEATKEVHIRAENSEFMRNFQKGQVSREGFKLVMASLYHIYTA
LEEEIERNKQNPVYAPLYFPEELHRRAALEQDMAFWYGPHWQEAIPYTPATQHYVKRLHE
VGGTHPELLVAHAYTRYLGDLSGGQVLKKIAQKAMALPSSGEGLAFFTFPSIDNPTKFKQ
LYRARMNTLEMTPEVKHRVTEEAKTAFLLNIELFEELQALLTEEHKDQSPSQTEFLRQRP
ASLVQDTTSAETPRGKSQISTSSSQTPLLRWVLTLSFLLATVAVGIYAM
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  Blast E-value cutoff:
BDBM50438664
n/a
NameBDBM50438664
Synonyms:CHEMBL2414447
TypeSmall organic molecule
Emp. Form.C12H13N3O3
Mol. Mass.247.2499
SMILES[O-][N+](=O)c1ccc(OCCCn2ccnc2)cc1
Structure
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