Reaction Details Report a problem with these data
Target
Arginase-1
Ligand
BDBM50350311
Substrate
n/a
Meas. Tech.
ChEMBL_978893 (CHEMBL2423684)
IC50
1470±n/a nM
Citation
 Golebiowski, A; Whitehouse, D; Beckett, RP; Van Zandt, M; Ji, MK; Ryder, TR; Jagdmann, E; Andreoli, M; Lee, Y; Sheeler, R; Conway, B; Olczak, J; Mazur, M; Czestkowski, W; Piotrowska, W; Cousido-Siah, A; Ruiz, FX; Mitschler, A; Podjarny, A; Schroeter, H Synthesis of quaternarya-amino acid-based arginase inhibitors via the Ugi reaction. Bioorg Med Chem Lett 23:4837-41 (2013) [PubMed]  Article 
Target
Name:
Arginase-1
Synonyms:
ARG1 | ARGI1_HUMAN | Liver-type arginase | Type I arginase
Type:
PROTEIN
Mol. Mass.:
34737.53
Organism:
Homo sapiens (Human)
Description:
ChEMBL_978893
Residue:
322
Sequence:
MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYLNPPK
  
Inhibitor
Name:
BDBM50350311
Synonyms:
CHEMBL1812661
Type:
Small organic molecule
Emp. Form.:
C6H14BNO4
Mol. Mass.:
174.991
SMILES:
[NH3+][C@@H](CCCCB(O)O)C([O-])=O |r|
Structure:
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