Reaction Details Report a problem with these data
Target
Arginase-2, mitochondrial
Ligand
BDBM50439234
Substrate
n/a
Meas. Tech.
ChEMBL_978892 (CHEMBL2423683)
IC50
1100±n/a nM
Citation
 Golebiowski, A; Whitehouse, D; Beckett, RP; Van Zandt, M; Ji, MK; Ryder, TR; Jagdmann, E; Andreoli, M; Lee, Y; Sheeler, R; Conway, B; Olczak, J; Mazur, M; Czestkowski, W; Piotrowska, W; Cousido-Siah, A; Ruiz, FX; Mitschler, A; Podjarny, A; Schroeter, H Synthesis of quaternarya-amino acid-based arginase inhibitors via the Ugi reaction. Bioorg Med Chem Lett 23:4837-41 (2013) [PubMed]  Article 
Target
Name:
Arginase-2, mitochondrial
Synonyms:
ARG2 | ARGI2_HUMAN | Arginase II | Kidney-type arginase | Non-hepatic arginase | Type II arginase
Type:
PROTEIN
Mol. Mass.:
38576.93
Organism:
Homo sapiens (Human)
Description:
ChEMBL_978892
Residue:
354
Sequence:
MSLRGSLSRLLQTRVHSILKKSVHSVAVIGAPFSQGQKRKGVEHGPAAIREAGLMKRLSSLGCHLKDFGDLSFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSDGYSCVTLGGDHSLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPGFSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDLLIGKRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTGLLSALDLVEVNPQLATSEEEAKTTANLAVDVIASSFGQTREGGHIVYDQLPTPSSPDESENQARVRI
  
Inhibitor
Name:
BDBM50439234
Synonyms:
CHEMBL2418826
Type:
Small organic molecule
Emp. Form.:
C18H27BClN3O5
Mol. Mass.:
411.688
SMILES:
NC(CCCCB(O)O)(C1CCN(CC1)C(=O)Nc1ccc(Cl)cc1)C(O)=O
Structure:
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