Reaction Details Report a problem with these data
Target
G protein-activated inward rectifier potassium channel 1
Ligand
BDBM50439416
Substrate
n/a
Meas. Tech.
ChEMBL_980173 (CHEMBL2424211)
EC50
>10000±n/a nM
Citation
 Ramos-Hunter, SJ; Engers, DW; Kaufmann, K; Du, Y; Lindsley, CW; Weaver, CD; Sulikowski, GA Discovery and SAR of a novel series of GIRK1/2 and GIRK1/4 activators. Bioorg Med Chem Lett 23:5195-8 (2013) [PubMed]  Article 
Target
Name:
G protein-activated inward rectifier potassium channel 1
Synonyms:
GIRK-1 | GIRK1 | Inward rectifier K(+) channel Kir3.1 | KCNJ3 | KCNJ3_HUMAN | Potassium channel, inwardly rectifying subfamily J member 3
Type:
PROTEIN
Mol. Mass.:
56610.74
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107915
Residue:
501
Sequence:
MSALRRKFGDDYQVVTTSSSGSGLQPQGPGQDPQQQLVPKKKRQRFVDKNGRCNVQHGNLGSETSRYLSDLFTTLVDLKWRWNLFIFILTYTVAWLFMASMWWVIAYTRGDLNKAHVGNYTPCVANVYNFPSAFLFFIETEATIGYGYRYITDKCPEGIILFLFQSILGSIVDAFLIGCMFIKMSQPKKRAETLMFSEHAVISMRDGKLTLMFRVGNLRNSHMVSAQIRCKLLKSRQTPEGEFLPLDQLELDVGFSTGADQLFLVSPLTICHVIDAKSPFYDLSQRSMQTEQFEIVVILEGIVETTGMTCQARTSYTEDEVLWGHRFFPVISLEEGFFKVDYSQFHATFEVPTPPYSVKEQEEMLLMSSPLIAPAITNSKERHNSVECLDGLDDITTKLPSKLQKITGREDFPKKLLRMSSTTSEKAYSLGDLPMKLQRISSVPGNSEEKLVSKTTKMLSDPMSQSVADLPPKLQKMAGGAARMEGNLPAKLRKMNSDRFT
  
Inhibitor
Name:
BDBM50439416
Synonyms:
CHEMBL2420548
Type:
Small organic molecule
Emp. Form.:
C18H23N3O5S
Mol. Mass.:
393.457
SMILES:
COc1ccc(OC)c(NC(=O)Nc2ccc(C)c(c2)S(=O)(=O)N(C)C)c1
Structure:
Search PDB for entries with ligand similarity: