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Target
SUMO-activating enzyme subunit 2
Ligand
BDBM96736
Substrate
n/a
Meas. Tech.
ChEMBL_977623 (CHEMBL2423590)
IC50
73000±n/a nM
Citation
Kumar, A; Ito, A; Hirohama, M; Yoshida, M; Zhang, KY Identification of quinazolinyloxy biaryl urea as a new class of SUMO activating enzyme 1 inhibitors. Bioorg Med Chem Lett 23:5145-9 (2013) [PubMed] Article
More Info.:
Target
Name:
SUMO-activating enzyme subunit 2
Synonyms:
6.3.2.- | Anthracycline-associated resistance ARX | SAE2 | SAE2_HUMAN | SUMO-activating enzyme subunit 2 | SUMO-activating enzyme subunit 2 (SAE2) | UBA2 | UBLE1B | Ubiquitin-like 1-activating enzyme E1B | Ubiquitin-like modifier-activating enzyme 2
Type:
Enzyme
Mol. Mass.:
71206.17
Organism:
Homo sapiens (Human)
Description:
Q9UBT2
Residue:
640
Sequence:
MALSRGLPRELAEAVAGGRVLVVGAGGIGCELLKNLVLTGFSHIDLIDLDTIDVSNLNRQFLFQKKHVGRSKAQVAKESVLQFYPKANIVAYHDSIMNPDYNVEFFRQFILVMNALDNRAARNHVNRMCLAADVPLIESGTAGYLGQVTTIKKGVTECYECHPKPTQRTFPGCTIRNTPSEPIHCIVWAKYLFNQLFGEEDADQEVSPDRADPEAAWEPTEAEARARASNEDGDIKRISTKEWAKSTGYDPVKLFTKLFKDDIRYLLTMDKLWRKRKPPVPLDWAEVQSQGEETNASDQQNEPQLGLKDQQVLDVKSYARLFSKSIETLRVHLAEKGDGAELIWDKDDPSAMDFVTSAANLRMHIFSMNMKSRFDIKSMAGNIIPAIATTNAVIAGLIVLEGLKILSGKIDQCRTIFLNKQPNPRKKLLVPCALDPPNPNCYVCASKPEVTVRLNVHKVTVLTLQDKIVKEKFAMVAPDVQIEDGKGTILISSEEGETEANNHKKLSEFGIRNGSRLQADDFLQDYTLLINILHSEDLGKDVEFEVVGDAPEKVGPKQAEDAAKSITNGSDDGAQPSTSTAQEQDDVLIVDSDEEDSSNNADVSEEERSRKRKLDEKENLSAKRSRIEQKEELDDVIALD
Inhibitor
Name:
BDBM96736
Synonyms:
1-[6-(7-chloranylquinazolin-4-yl)oxypyridin-3-yl]-3-(4-fluorophenyl)urea | 1-[6-(7-chloroquinazolin-4-yl)oxy-3-pyridyl]-3-(4-fluorophenyl)urea | 1-[6-(7-chloroquinazolin-4-yl)oxypyridin-3-yl]-3-(4-fluorophenyl)urea | 1-[6-[(7-chloro-4-quinazolinyl)oxy]-3-pyridinyl]-3-(4-fluorophenyl)urea | MLS000860602 | N-{6-[(7-chloro-4-quinazolinyl)oxy]-3-pyridinyl}-N'-(4-fluorophenyl)urea | SMR000458686 | cid_2814119
Type:
Small organic molecule
Emp. Form.:
C20H13ClFN5O2
Mol. Mass.:
409.801
SMILES:
Fc1ccc(NC(=O)Nc2ccc(Oc3ncnc4cc(Cl)ccc34)nc2)cc1