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Target
SUMO-activating enzyme subunit 2
Ligand
BDBM50439442
Substrate
n/a
Meas. Tech.
ChEMBL_977624 (CHEMBL2423591)
IC50
14400±n/a nM
Citation
 Kumar, A; Ito, A; Hirohama, M; Yoshida, M; Zhang, KY Identification of quinazolinyloxy biaryl urea as a new class of SUMO activating enzyme 1 inhibitors. Bioorg Med Chem Lett 23:5145-9 (2013) [PubMed]  Article 
Target
Name:
SUMO-activating enzyme subunit 2
Synonyms:
6.3.2.- | Anthracycline-associated resistance ARX | SAE2 | SAE2_HUMAN | SUMO-activating enzyme subunit 2 | SUMO-activating enzyme subunit 2 (SAE2) | UBA2 | UBLE1B | Ubiquitin-like 1-activating enzyme E1B | Ubiquitin-like modifier-activating enzyme 2
Type:
Enzyme
Mol. Mass.:
71206.17
Organism:
Homo sapiens (Human)
Description:
Q9UBT2
Residue:
640
Sequence:
MALSRGLPRELAEAVAGGRVLVVGAGGIGCELLKNLVLTGFSHIDLIDLDTIDVSNLNRQFLFQKKHVGRSKAQVAKESVLQFYPKANIVAYHDSIMNPDYNVEFFRQFILVMNALDNRAARNHVNRMCLAADVPLIESGTAGYLGQVTTIKKGVTECYECHPKPTQRTFPGCTIRNTPSEPIHCIVWAKYLFNQLFGEEDADQEVSPDRADPEAAWEPTEAEARARASNEDGDIKRISTKEWAKSTGYDPVKLFTKLFKDDIRYLLTMDKLWRKRKPPVPLDWAEVQSQGEETNASDQQNEPQLGLKDQQVLDVKSYARLFSKSIETLRVHLAEKGDGAELIWDKDDPSAMDFVTSAANLRMHIFSMNMKSRFDIKSMAGNIIPAIATTNAVIAGLIVLEGLKILSGKIDQCRTIFLNKQPNPRKKLLVPCALDPPNPNCYVCASKPEVTVRLNVHKVTVLTLQDKIVKEKFAMVAPDVQIEDGKGTILISSEEGETEANNHKKLSEFGIRNGSRLQADDFLQDYTLLINILHSEDLGKDVEFEVVGDAPEKVGPKQAEDAAKSITNGSDDGAQPSTSTAQEQDDVLIVDSDEEDSSNNADVSEEERSRKRKLDEKENLSAKRSRIEQKEELDDVIALD
  
Inhibitor
Name:
BDBM50439442
Synonyms:
CHEMBL2420737
Type:
Small organic molecule
Emp. Form.:
C29H28N4O2
Mol. Mass.:
464.5582
SMILES:
Cc1cccc(NC(=O)Nc2ccc(Cc3ccc(NC(=O)Nc4cccc(C)c4)cc3)cc2)c1
Structure:
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