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TargetN-acylethanolamine-hydrolyzing acid amidase (NAAA)
LigandBDBM50439652
Substrate/Competitorn/a
Meas. Tech.ChEMBL_978417
IC50 310±n/a nM
Citation Ponzano, SBertozzi, FMengatto, LDionisi, MArmirotti, ARomeo, EBerteotti, AFiorelli, CTarozzo, GReggiani, ADuranti, ATarzia, GMor, MCavalli, APiomelli, DBandiera, T Synthesis and structure-activity relationship (SAR) of 2-methyl-4-oxo-3-oxetanylcarbamic acid esters, a class of potent N-acylethanolamine acid amidase (NAAA) inhibitors. J Med Chem56:6917-34 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
N-acylethanolamine-hydrolyzing acid amidase (NAAA)
Name:N-acylethanolamine-hydrolyzing acid amidase (NAAA)
Synonyms:ASAH-like protein | Asahl | N-acylethanolamine acid amidase (NAAA) | N-acylethanolamine-hydrolyzing acid amidase | N-acylethanolamine-hydrolyzing acid amidase subunit alpha | N-acylethanolamine-hydrolyzing acid amidase subunit beta | N-acylsphingosine amidohydrolase-like | Naaa
Type:Enzyme
Mol. Mass.:40306.53
Organism:Rattus norvegicus (Rat)
Description:Q5KTC7
Residue:362
Sequence:
MGTPAIRAACHGAHLALALLLLLSLSDPWLWATAPGTPPLFNVSLDAAPELRWLPMLQHY
DPDFVRAAVAQVIGDRVPQWILEMIGEIVQKVESFLPQPFTSEIRGICDYLNLSLAEGVL
VNLAYEASAFCTSIVAQDSQGRIYHGRNLDYPFGNALRKLTADVQFVKNGQIVFTATTFV
GYVGLWTGQSPHKFTISGDERDKGWWWENMIAALSLGHSPISWLIRKTLTESEDFEAAVY
TLAKTPLIADVYYIVGGTSPQEGVVITRDRGGPADIWPLDPLNGAWFRVETNYDHWEPVP
KRDDRRTPAIKALNATGQAHLSLETLFQVLSVFPVYNNYTIYTTVMSAAEPDKYMTMIRN
PS
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BDBM50439652
NameBDBM50439652
Synonyms:CHEMBL2419809 | US9353075, 25
TypeSmall organic molecule
Emp. Form.C18H25NO4
Mol. Mass.319.3954
SMILESC[C@@H]1OC(=O)[C@@H]1NC(=O)OC(C)(C)CCCCc1ccccc1 |r|
Structure
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n/a