Reaction Details Report a problem with these data
Target
Dual specificity protein phosphatase 10
Ligand
BDBM50441297
Substrate
n/a
Meas. Tech.
ChEMBL_984915 (CHEMBL2432854)
Ki
340000±n/a nM
Citation
 Baguley, TD; Xu, HC; Chatterjee, M; Nairn, AC; Lombroso, PJ; Ellman, JA Substrate-based fragment identification for the development of selective, nonpeptidic inhibitors of striatal-enriched protein tyrosine phosphatase. J Med Chem 56:7636-50 (2013) [PubMed]  Article 
Target
Name:
Dual specificity protein phosphatase 10
Synonyms:
DUS10_HUMAN | DUSP10 | Dual specificity protein phosphatase 10 | MAP kinase phosphatase 5 | MKP-5 | MKP5 | Mitogen-activated protein kinase phosphatase 5 | Mitogen-activated protein kinase phosphatase 5 (MKP5)
Type:
Enzyme
Mol. Mass.:
52649.12
Organism:
Homo sapiens (Human)
Description:
Q9Y6W6
Residue:
482
Sequence:
MPPSPLDDRVVVALSRPVRPQDLNLCLDSSYLGSANPGSNSHPPVIATTVVSLKAANLTYMPSSSGSARSLNCGCSSASCCTVATYDKDNQAQTQAIAAGTTTTAIGTSTTCPANQMVNNNENTGSLSPSSGVGSPVSGTPKQLASIKIIYPNDLAKKMTKCSKSHLPSQGPVIIDCRPFMEYNKSHIQGAVHINCADKISRRRLQQGKITVLDLISCREGKDSFKRIFSKEIIVYDENTNEPSRVMPSQPLHIVLESLKREGKEPLVLKGGLSSFKQNHENLCDNSLQLQECREVGGGASAASSLLPQPIPTTPDIENAELTPILPFLFLGNEQDAQDLDTMQRLNIGYVINVTTHLPLYHYEKGLFNYKRLPATDSNKQNLRQYFEEAFEFIEEAHQCGKGLLIHCQAGVSRSATIVIAYLMKHTRMTMTDAYKFVKGKRPIISPNLNFMGQLLEFEEDLNNGVTPRILTPKLMGVETVV
  
Inhibitor
Name:
BDBM50441297
Synonyms:
CHEMBL2431664 | CHEMBL2431666
Type:
Small organic molecule
Emp. Form.:
C20H17Cl2O5P
Mol. Mass.:
439.226
SMILES:
O[C@H](c1cccc(c1)-c1ccc(cc1)C(=O)P(O)(O)O)c1ccc(Cl)c(Cl)c1 |r|
Structure:
Search PDB for entries with ligand similarity: