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Target
Histamine H3 receptor
Ligand
BDBM50441642
Substrate
n/a
Meas. Tech.
ChEMBL_986995 (CHEMBL2439315)
Kd
2.0±n/a nM
Citation
 Zeng, Q; Rosenblum, SB; Yang, Z; Jiang, Y; McCormick, KD; Aslanian, RG; Duguma, L; Kozlowski, JA; Shih, NY; Hey, JA; West, RE; Korfmacher, WA; Berlin, M; Boyce, CW Synthesis and SAR studies of benzimidazolone derivatives as histamine H3-receptor antagonists. Bioorg Med Chem Lett 23:6001-3 (2013) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
HISTAMINE H3 | HRH3 | HRH3_CAVPO | Histamine H3 receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48753.61
Organism:
GUINEA PIG
Description:
HISTAMINE H3 HRH3 GUINEA PIG::Q9JI35
Residue:
445
Sequence:
MERAPPDGLMNASGALAGEAAAAAGGARTFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGVFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMVLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGAREAGPDPLPEAQSSPPQPPPGCWGCWPKGQGESMPLHRYGVGEAGPGAEAGEAALGGGSGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHSSLEHCWK
  
Inhibitor
Name:
BDBM50441642
Synonyms:
CHEMBL2437425
Type:
Small organic molecule
Emp. Form.:
C26H30F4N6O2
Mol. Mass.:
534.549
SMILES:
Nc1cc(CN2CCC(CC2)C(=O)N2CCC(CC2)n2c3ccc(F)cc3n(CC(F)(F)F)c2=O)ccn1
Structure:
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