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Target
Cytohesin-2
Ligand
BDBM50441973
Substrate
n/a
Meas. Tech.
ChEMBL_992400 (CHEMBL2445620)
Ki
1610000±n/a nM
Citation
 Rouhana, J; Hoh, F; Estaran, S; Henriquet, C; Boublik, Y; Kerkour, A; Trouillard, R; Martinez, J; Pugnière, M; Padilla, A; Chavanieu, A Fragment-based identification of a locus in the Sec7 domain of Arno for the design of protein-protein interaction inhibitors. J Med Chem 56:8497-511 (2013) [PubMed]  Article 
Target
Name:
Cytohesin-2
Synonyms:
ARF exchange factor | ARF nucleotide-binding site opener | ARNO | CYH2_HUMAN | CYTH2 | PH, SEC7 and coiled-coil domain-containing protein 2 | PSCD2 | PSCD2L | Protein ARNO
Type:
PROTEIN
Mol. Mass.:
46539.02
Organism:
Homo sapiens (Human)
Description:
ChEMBL_102649
Residue:
400
Sequence:
MEDGVYEPPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEGSKTLQRNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSIRNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQEEKDEWIKSIQAAVSVDPFYEMLAARKKRISVKKKQEQP
  
Inhibitor
Name:
BDBM50441973
Synonyms:
CHEMBL2440218
Type:
Small organic molecule
Emp. Form.:
C15H17NO4S
Mol. Mass.:
307.365
SMILES:
COc1ccc(cc1)S(=O)(=O)Nc1c(C)cc(O)cc1C
Structure:
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