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Target
Tissue alpha-L-fucosidase
Ligand
BDBM50442348
Substrate
n/a
Meas. Tech.
ChEMBL_990951 (CHEMBL2445279)
IC50
43±n/a nM
Citation
 Kato, A; Okaki, T; Ifuku, S; Sato, K; Hirokami, Y; Iwaki, R; Kamori, A; Nakagawa, S; Adachi, I; Kiria, PG; Onomura, O; Minato, D; Sugimoto, K; Matsuya, Y; Toyooka, N Synthesis and biological evaluation of N-(2-fluorophenyl)-2ß-deoxyfuconojirimycin acetamide as a potent inhibitor fora-l-fucosidases. Bioorg Med Chem 21:6565-73 (2013) [PubMed]  Article 
Target
Name:
Tissue alpha-L-fucosidase
Synonyms:
Alpha-L-fucosidase 1 | FUCA1 | FUCO_BOVIN
Type:
PROTEIN
Mol. Mass.:
54093.12
Organism:
Bos taurus
Description:
ChEMBL_335897
Residue:
468
Sequence:
MRSWVVGARLLLLLQLVLVLGAVRLPPCTDPRHCTDPPRYTPDWPSLDSRPLPAWFDEAKFGVFVHWGVFSVPAWGSEWFWWHWQGEKLPQYESFMKENYPPDFSYADFGPRFTARFFNPDSWADLFKAAGAKYVVLTTKHHEGYTNWPSPVSWNWNSKDVGPHRDLVGELGTAIRKRNIRYGLYHSLLEWFHPLYLRDKKNGFKTQYFVNAKTMPELYDLVNRYKPDLIWSDGEWECPDTYWNSTDFLAWLYNDSPVKDEVVVNDRWGQNCSCHHGGYYNCKDKFQPETLPDHKWEMCTSIDQRSWGYRRDMEMADITNESTIISELVQTVSLGGNYLLNVGPTKDGLIVPIFQERLLAVGKWLSINGEAIYASKPWRVQSEKNSVWYTSKGLAVYAILLHWPEYGILSLISPIATSTTKVTMLGIQKDLKWSLNPSGKGLLVFLPQLPPAALPTEFAWTIKLTGVK
  
Inhibitor
Name:
BDBM50442348
Synonyms:
CHEMBL2442779
Type:
Small organic molecule
Emp. Form.:
C15H22N2O5
Mol. Mass.:
310.3456
SMILES:
COc1ccc(NC(=O)C[C@H]2N[C@@H](C)[C@@H](O)[C@@H](O)[C@@H]2O)cc1 |r|
Structure:
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