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Target
Egl nine homolog 1
Ligand
BDBM50385858
Substrate
n/a
Meas. Tech.
ChEMBL_989568 (CHEMBL2444624)
IC50
25±n/a nM
Citation
 Deng, G; Zhao, B; Ma, Y; Xu, Q; Wang, H; Yang, L; Zhang, Q; Guo, TB; Zhang, W; Jiao, Y; Cai, X; Zhang, J; Liu, H; Guan, X; Lu, H; Xiang, J; Elliott, JD; Lin, X; Ren, F Novel complex crystal structure of prolyl hydroxylase domain-containing protein 2 (PHD2): 2,8-Diazaspiro[4.5]decan-1-ones as potent, orally bioavailable PHD2 inhibitors. Bioorg Med Chem 21:6349-58 (2013) [PubMed]  Article 
Target
Name:
Egl nine homolog 1
Synonyms:
C1orf12 | EGLN1 | EGLN1_HUMAN | Egl nine homolog 1 (EGLN1) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIFPH2) | Prolyl hydroxylase domain-containing protein 2 (PHD2)
Type:
Protein
Mol. Mass.:
46035.59
Organism:
Homo sapiens (Human)
Description:
Q9GZT9
Residue:
426
Sequence:
MANDSGGPGGPSPSERDRQYCELCGKMENLLRCSRCRSSFYCCKEHQRQDWKKHKLVCQGSEGALGHGVGPHQHSGPAPPAAVPPPRAGAREPRKAAARRDNASGDAAKGKVKAKPPADPAAAASPCRAAAGGQGSAVAAEAEPGKEEPPARSSLFQEKANLYPPSNTPGDALSPGGGLRPNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPSDSVGKDVF
  
Inhibitor
Name:
BDBM50385858
Synonyms:
CHEMBL2042997
Type:
Small organic molecule
Emp. Form.:
C27H29N3O
Mol. Mass.:
411.5387
SMILES:
Cc1cccnc1CN1CCC2(CCN(C2=O)c2ccc(cc2)-c2ccccc2)CC1
Structure:
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