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Target
Endothelial lipase
Ligand
BDBM50443625
Substrate
n/a
Meas. Tech.
ChEMBL_1279835 (CHEMBL3095694)
IC50
31±n/a nM
Citation
 Abdel-Magid, AF Endothelial lipase inhibitors for the treatment of atherosclerosis and cardiovascular disorders. ACS Med Chem Lett 4:1016-7 (2013) [PubMed]  Article 
Target
Name:
Endothelial lipase
Synonyms:
EDL | Endothelial cell-derived lipase | Endothelial lipase | Endothelial lipase (EL) | LIPE_MOUSE | Lipg
Type:
Protein
Mol. Mass.:
56643.58
Organism:
Mus musculus (Mouse)
Description:
Q9WVG5
Residue:
500
Sequence:
MRNTVFLLGFWSVYCYFPAGSITTLRPQGSLRDEHHKPTGVPATARPSVAFNIRTSKDPEQEGCNLSLGDSKLLENCGFNMTAKTFFIIHGWTMSGMFESWLHKLVSALQMREKDANVVVVDWLPLAHQLYTDAVNNTRVVGQRVAGMLDWLQEKEEFSLGNVHLIGYSLGAHVAGYAGNFVKGTVGRITGLDPAGPMFEGVDINRRLSPDDADFVDVLHTYTLSFGLSIGIRMPVGHIDIYPNGGDFQPGCGFNDVIGSFAYGTISEMVKCEHERAVHLFVDSLVNQDKPSFAFQCTDSSRFKRGICLSCRKNRCNNIGYNAKKMRKKRNSKMYLKTRAGMPFKVYHYQLKVHMFSYNNSGDTQPTLYITLYGSNADSQNLPLEIVEKIELNATNTFLVYTEEDLGDLLKMRLTWEGVAHSWYNLWNEFRNYLSQPSNPSRELYIRRIRVKSGETQRKVTFCTQDPTKSSISPGQELWFHKCQDGWKMKNKTSPFVNLA
  
Inhibitor
Name:
BDBM50443625
Synonyms:
CHEMBL3092448 | US9216998, 25
Type:
Small organic molecule
Emp. Form.:
C19H16F3NO
Mol. Mass.:
331.3316
SMILES:
FC(F)(F)c1c(CCc2ccccc2)n2CCOc3cccc1c23
Structure:
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