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Target
Dual specificity protein kinase CLK3
Ligand
BDBM50443638
Substrate
n/a
Meas. Tech.
ChEMBL_1280768 (CHEMBL3097752)
IC50
550±n/a nM
Citation
 Burgy, G; Tahtouh, T; Durieu, E; Foll-Josselin, B; Limanton, E; Meijer, L; Carreaux, F; Bazureau, JP Chemical synthesis and biological validation of immobilized protein kinase inhibitory Leucettines. Eur J Med Chem 62:728-37 (2013) [PubMed]  Article 
Target
Name:
Dual specificity protein kinase CLK3
Synonyms:
CDC-like kinase 3 | CLK3_MOUSE | Clk3
Type:
PROTEIN
Mol. Mass.:
73855.32
Organism:
Mus musculus
Description:
ChEMBL_1502247
Residue:
638
Sequence:
MPVLSARRKRLASTAGPRRGSGPSLAVRWVPPLGPEPSSDRGRAPMRPRGPTCSTTRRGAGRGPRLLPGPPGRDLHRCRPDPGGAGQSPRVCEFGARAVRPLGRVEPGPPTAASREGAVLPRAEARAGSGRGARSGEWGLAAAGAWETMHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRIPYQRRYREHRDSDTYRCEERSPSFGEDCYGSSRSRHRRRSRERAPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHSSRNPSR
  
Inhibitor
Name:
BDBM50443638
Synonyms:
CHEMBL3092863
Type:
Small organic molecule
Emp. Form.:
C25H30N4O7
Mol. Mass.:
498.5283
SMILES:
NCCOCCOCCOCCOc1ccc(NC2=NC(=Cc3ccc4OCOc4c3)C(=O)N2)cc1 |w:21.21,t:18|
Structure:
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