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Target
Sonic hedgehog protein
Ligand
BDBM50443893
Substrate
n/a
Meas. Tech.
ChEMBL_1277855 (CHEMBL3097789)
IC50
1.6±n/a nM
Citation
 Xin, M; Wen, J; Tang, F; Tu, C; Shen, H; Zhao, X The discovery of novel N-(2-pyrimidinylamino) benzamide derivatives as potent hedgehog signaling pathway inhibitors. Bioorg Med Chem Lett 23:6777-83 (2013) [PubMed]  Article 
Target
Name:
Sonic hedgehog protein
Synonyms:
Hhg1 | SHH_MOUSE | Shh
Type:
Protein
Mol. Mass.:
47784.50
Organism:
Mus musculus (Mouse)
Description:
Q62226
Residue:
437
Sequence:
MLLLLARCFLVILASSLLVCPGLACGPGRGFGKRRHPKKLTPLAYKQFIPNVAEKTLGASGRYEGKITRNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNALAISVMNQWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESKAHIHCSVKAENSVAAKSGGCFPGSATVHLEQGGTKLVKDLRPGDRVLAADDQGRLLYSDFLTFLDRDEGAKKVFYVIETLEPRERLLLTAAHLLFVAPHNDSGPTPGPSALFASRVRPGQRVYVVAERGGDRRLLPAAVHSVTLREEEAGAYAPLTAHGTILINRVLASCYAVIEEHSWAHRAFAPFRLAHALLAALAPARTDGGGGGSIPAAQSATEARGAEPTAGIHWYSQLLYHIGTWLLDSETMHPLGMAVKSS
  
Inhibitor
Name:
BDBM50443893
Synonyms:
CHEMBL3091548
Type:
Small organic molecule
Emp. Form.:
C28H25F3N4O2
Mol. Mass.:
506.5189
SMILES:
Cc1cccc(C)c1NC(=O)c1ccc(Nc2nc(C)c(C)c(n2)-c2ccc(OC(F)(F)F)cc2)cc1
Structure:
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