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TargetBeta-ketoacyl-ACP synthase III (FabH)
LigandBDBM50368267
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1281878
IC50 6300±n/a nM
Citation Zhang, FWen, QWang, SFShahla Karim, BYang, YSLiu, JJZhang, WMZhu, HL Design, synthesis and antibacterial activities of 5-(pyrazin-2-yl)-4H-1,2,4-triazole-3-thiol derivatives containing Schiff base formation as FabH inhibitory. Bioorg Med Chem Lett24:90-5 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Beta-ketoacyl-ACP synthase III (FabH)
Name:Beta-ketoacyl-ACP synthase III (FabH)
Synonyms:3-oxoacyl-[acyl-carrier-protein] synthase | 3-oxoacyl-[acyl-carrier-protein] synthase 3 | 3-oxoacyl-[acyl-carrier-protein] synthase III
Type:Enzyme
Mol. Mass.:33506.68
Organism:Escherichia coli
Description:C3TDZ2
Residue:317
Sequence:
MYTKIIGTGSYLPEQVRTNADLEKMVDTSDEWIVTRTGIRERHIAAPNETVSTMGFEAAT
RAIEMAGIEKDQIGLIVVATTSATHAFPSAACQIQSMLGIKGCPAFDVAAACAGFTYALS
VADQYVKSGAVKYALVVGSDVLARTCDPTDRGTIIIFGDGAGAAVLAASEEPGIISTHLH
ADGSYGELLTLPNADRVNPENSIHLTMAGNEVFKVAVTELAHIVDETLAANNLDRSQLDW
LVPHQANLRIISATAKKLGMSMDNVVVTLDRHGNTSAASVPCALDEAVRDGRIKPGQLVL
LEAFGGGFTWGSALVRF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50368267
NameBDBM50368267
Synonyms:KANAMYCIN B | Kanamycin | Kantrex | Klebcil
TypeSmall organic molecule
Emp. Form.C18H37N5O10
Mol. Mass.483.5139
SMILESNC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](N)[C@@H](O)[C@@H]1O |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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