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Target
Peroxisome proliferator-activated receptor gamma
Ligand
BDBM50448029
Substrate
n/a
Meas. Tech.
ChEMBL_1288928 (CHEMBL3117625)
EC50
270±n/a nM
Citation
 Lamotte, Y; Faucher, N; Sançon, J; Pineau, O; Sautet, S; Fouchet, MH; Beneton, V; Tousaint, JJ; Saintillan, Y; Ancellin, N; Nicodeme, E; Grillot, D; Martres, P Discovery of novel indazole derivatives as dual angiotensin II antagonists and partial PPAR¿ agonists. Bioorg Med Chem Lett 24:1098-103 (2014) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor gamma
Synonyms:
Nr1c3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG_MOUSE | Pparg
Type:
PROTEIN
Mol. Mass.:
57593.55
Organism:
Mus musculus
Description:
ChEMBL_1453700
Residue:
505
Sequence:
MGETLGDSPVDPEHGAFADALPMSTSQEITMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISAPHYEDIPFTRADPMVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNRPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKNIPGFINLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKNLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKVLQKMTDLRQIVTEHVQLLHVIKKTETDMSLHPLLQEIYKDLY
  
Inhibitor
Name:
BDBM50448029
Synonyms:
CHEMBL3115247
Type:
Small organic molecule
Emp. Form.:
C35H34N8
Mol. Mass.:
566.6981
SMILES:
CCCCn1c(nc2ccccc12)-c1ccc2nn(CCC)c(Cc3ccc(cc3)-c3ccccc3-c3nnn[nH]3)c2c1
Structure:
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