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TargetSerine/threonine-protein kinase PAK7
LigandBDBM50448771
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1294403
IC50 126±n/a nM
Citation Staben, ST; Feng, JA; Lyle, K; Belvin, M; Boggs, J; Burch, JD; Chua, CC; Cui, H; DiPasquale, AG; Friedman, LS; Heise, C; Koeppen, H; Kotey, A; Mintzer, R; Oh, A; Roberts, DA; Rouge, L; Rudolph, J; Tam, C; Wang, W; Xiao, Y; Young, A; Zhang, Y; Hoeflich, KP Back pocket flexibility provides group II p21-activated kinase (PAK) selectivity for type I 1/2 kinase inhibitors. J Med Chem57:1033-45 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Serine/threonine-protein kinase PAK7
Name:Serine/threonine-protein kinase PAK7
Synonyms:PAK7/PAK5 | Protein Kinase PAK5 | Serine/threonine-protein kinase (PAK7) | Serine/threonine-protein kinase PAK 5
Type:Protein
Mol. Mass.:80760.58
Organism:Homo sapiens (Human)
Description:Q9P286
Residue:719
Sequence:
MFGKKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPKPMVDPSCIT
PIQLAPMKTIVRGNKPCKETSINGLLEDFDNISVTRSNSLRKESPPTPDQGASSHGPGHA
EENGFITFSQYSSESDTTADYTTEKYREKSLYGDDLDPYYRGSHAAKQNGHVMKMKHGEA
YYSEVKPLKSDFARFSADYHSHLDSLSKPSEYSDLKWEYQRASSSSPLDYSFQFTPSRTA
GTSGCSKESLAYSESEWGPSLDDYDRRPKSSYLNQTSPQPTMRQRSRSGSGLQEPMMPFG
ASAFKTHPQGHSYNSYTYPRLSEPTMCIPKVDYDRAQMVLSPPLSGSDTYPRGPAKLPQS
QSKSGYSSSSHQYPSGYHKATLYHHPSLQSSSQYISTASYLSSLSLSSSTYPPPSWGSSS
DQQPSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKM
DLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRM
NEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKR
KSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLP
PRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLMRQYRHH
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50448771
NameBDBM50448771
Synonyms:CHEMBL3128042
TypeSmall organic molecule
Emp. Form.C22H26N6O2
Mol. Mass.406.4808
SMILESCOCCNc1nc2ccc(cc2n1-c1ccnc(N)n1)C#CC1(O)CCCCC1
Structure
n/a