Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 5
Ligand
BDBM50449319
Substrate
n/a
Meas. Tech.
ChEMBL_1296657 (CHEMBL3131566)
Ki
12±n/a nM
Citation
 Burns, JF; Chen, B; Chen, CA; Doller, D; Edelmenky, E; Jiang, Y; Peterson, JM; Sabio, M; Weiss, J; White, AD; Wu, L; Bhardwaj, R; Chandrasena, G; Boyle, NJ; Huang, X cis-1-Oxo-heterocyclyl-4-amido cyclohexane derivatives as NPY5 receptor antagonists. Bioorg Med Chem Lett 24:1458-61 (2014) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY-Y5 receptor | NPY5-R | NPY5R | NPY5R_HUMAN | NPYR5 | NPYY5 | Neuropeptide Y receptor type 5 | Neuropeptide Y receptor type 5 ( NPY Y5) | Y5 receptor
Type:
Enzyme
Mol. Mass.:
50746.64
Organism:
Homo sapiens (Human)
Description:
Q15761
Residue:
445
Sequence:
MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
  
Inhibitor
Name:
BDBM50449319
Synonyms:
CHEMBL3126049
Type:
Small organic molecule
Emp. Form.:
C23H26F2N4O2
Mol. Mass.:
428.4749
SMILES:
CN1CCCN([C@H]2CC[C@H](CC2)C(=O)Nc2ccc(cn2)-c2cc(F)cc(F)c2)C1=O |r,wU:9.12,6.5,(29.98,-38.65,;29.2,-39.98,;29.96,-41.32,;29.19,-42.65,;27.65,-42.65,;26.88,-41.31,;25.34,-41.3,;24.57,-42.63,;23.03,-42.62,;22.26,-41.28,;23.04,-39.95,;24.58,-39.96,;20.72,-41.28,;19.96,-39.94,;19.95,-42.61,;18.41,-42.6,;17.63,-43.93,;16.09,-43.92,;15.33,-42.59,;16.1,-41.25,;17.64,-41.26,;13.79,-42.58,;13.02,-41.24,;11.48,-41.23,;10.72,-39.89,;10.71,-42.56,;11.47,-43.9,;10.7,-45.23,;13.01,-43.9,;27.66,-39.97,;26.9,-38.63,)|
Structure:
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