Reaction Details Report a problem with these data
Target
Thymidine kinase, cytosolic
Ligand
BDBM50404860
Substrate
n/a
Meas. Tech.
ChEMBL_1333889 (CHEMBL3231778)
Ki
24000±n/a nM
Citation
 Hampton, A; Kappler, F; Chawla, RR Design of species- or isozyme-specific enzyme inhibitors. 1. Effect of thymidine substituents on affinity for the thymidine site of hamster cytoplasmic thymidine kinase. J Med Chem 22:621-31 (1979) [PubMed]  Article 
Target
Name:
Thymidine kinase, cytosolic
Synonyms:
KITH_MOUSE | Tk-1 | Tk1
Type:
PROTEIN
Mol. Mass.:
25782.68
Organism:
Mus musculus
Description:
ChEMBL_12706
Residue:
233
Sequence:
MSYINLPTVLPSSPSKTRGQIQVILGPMFSGKSTELMRRVRRFQIAQYKCLVIKYAKDTRYSNSFSTHDRNTMDALPACMLRDVTQESLGVAVIGIDEGQFFPDIVDFCEMMANEGKTVIVAALDGTFQRKAFGSILNLVPLAESVVKLTAVCMECFREAAYTKRLGLEKEVEVIGGADKYHSVCRLCYFKKSSAQTAGSDNKNCLVLGQPGEALVVRKLFASQQVLQYNSAN
  
Inhibitor
Name:
BDBM50404860
Synonyms:
CHEMBL2111285
Type:
Small organic molecule
Emp. Form.:
C12H19BrN2O6
Mol. Mass.:
367.193
SMILES:
CCOC1N([C@H]2C[C@H](O)[C@@H](CO)O2)C(=O)NC(=O)C1(C)Br |r|
Structure:
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