Target
G-protein coupled bile acid receptor 1
Ligand
BDBM50003286
Substrate
n/a
Meas. Tech.
ChEMBL_1335565 (CHEMBL3239420)
EC50
274±n/a nM
Citation
 Phillips, DPGao, WYang, YZhang, GLerario, IKLau, TLJiang, JWang, XNguyen, DGBhat, BGTrotter, CSullivan, HWelzel, GLandry, JChen, YJoseph, SBLi, CGordon, WPRichmond, WJohnson, KBretz, ABursulaya, BPan, SMcNamara, PSeidel, HM Discovery of trifluoromethyl(pyrimidin-2-yl)azetidine-2-carboxamides as potent, orally bioavailable TGR5 (GPBAR1) agonists: structure-activity relationships, lead optimization, and chronic in vivo efficacy. J Med Chem 57:3263-82 (2014) [PubMed]  Article 
Target
Name:
G-protein coupled bile acid receptor 1
Synonyms:
BG37 | GPBAR1 | GPBAR_HUMAN | M-BAR | TGR5 | hBG37 | hGPCR19
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
35260.02
Organism:
Homo sapiens (Human)
Description:
CHO cells transiently transfected with hTGR5.
Residue:
330
Sequence:
MTPNSTGEVPSPIPKGALGLSLALASLIITANLLLALGIAWDRRLRSPPAGCFFLSLLLAGLLTGLALPTLPGLWNQSRRGYWSCLLVYLAPNFSFLSLLANLLLVHGERYMAVLRPLQPPGSIRLALLLTWAGPLLFASLPALGWNHWTPGANCSSQAIFPAPYLYLEVYGLLLPAVGAAAFLSVRVLATAHRQLQDICRLERAVCRDEPSALARALTWRQARAQAGAMLLFGLCWGPYVATLLLSVLAYEQRPPLGPGTLLSLLSLGSASAAAVPVAMGLGDQRYTAPWRAAAQRCLQGLWGRASRDSPGPSIAYHPSSQSSVDLDLN
  
Inhibitor
Name:
BDBM50003286
Synonyms:
CHEMBL3234576
Type:
Small organic molecule
Emp. Form.:
C24H28F3N7O
Mol. Mass.:
487.5206
SMILES:
CN1CCN(CC1)c1cc(nc(n1)C(F)(F)F)N1CCC[C@@H]1C(=O)NCCc1ccc(cc1)C#N |r|
Structure:
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