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TargetG-protein coupled bile acid receptor 1
LigandBDBM50003336
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1335566
EC50 3.0±n/a nM
Citation Phillips, DPGao, WYang, YZhang, GLerario, IKLau, TLJiang, JWang, XNguyen, DGBhat, BGTrotter, CSullivan, HWelzel, GLandry, JChen, YJoseph, SBLi, CGordon, WPRichmond, WJohnson, KBretz, ABursulaya, BPan, SMcNamara, PSeidel, HM Discovery of trifluoromethyl(pyrimidin-2-yl)azetidine-2-carboxamides as potent, orally bioavailable TGR5 (GPBAR1) agonists: structure-activity relationships, lead optimization, and chronic in vivo efficacy. J Med Chem57:3263-82 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
G-protein coupled bile acid receptor 1
Name:G-protein coupled bile acid receptor 1
Synonyms:M-BAR | Membrane-type receptor for bile acids
Type:PROTEIN
Mol. Mass.:35665.78
Organism:Mus musculus
Description:ChEMBL_1475560
Residue:329
Sequence:
MMTPNSTELSAIPMGVLGLSLALASLIVIANLLLALGIALDRHLRSPPAGCFFLSLLLAG
LLTGLALPMLPGLWSRNHQGYWSCLLLHLTPNFCFLSLLANLLLVHGERYMAVLQPLRPH
GSVRLALFLTWVSSLFFASLPALGWNHWSPDANCSSQAVFPAPYLYLEVYGLLLPAVGAT
ALLSVRVLATAHRQLCEIRRLERAVCRDVPSTLARALTWRQARAQAGATLLFLLCWGPYV
ATLLLSVLAYERRPPLGPGTLLSLISLGSTSAAAVPVAMGLGDQRYTAPWRTAAQRCLRV
LRGRAKRDNPGPSTAYHTSSQCSIDLDLN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50003336
NameBDBM50003336
Synonyms:CHEMBL3234565
TypeSmall organic molecule
Emp. Form.C25H30F3N7O
Mol. Mass.501.5472
SMILESCN1CCN(CC1)c1cc(nc(n1)N1CCC[C@H](C1)C(=O)NCCc1ccc(cc1)C#N)C(F)(F)F |r|
Structure
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