Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50006607
Substrate
n/a
Meas. Tech.
ChEMBL_1334688 (CHEMBL3238571)
Ki
27±n/a nM
Citation
 Mach, RH; Zeng, C; Hawkins, WG Thes2 receptor: a novel protein for the imaging and treatment of cancer. J Med Chem 56:7137-60 (2013) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Opioid receptor | Oprs1 | SGMR1_RAT | Sigma | Sigma non-opioid intracellular receptor 1 | Sigma opioid receptor | Sigma-1 | Sigmar1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25266.54
Organism:
RAT
Description:
Q9R0C9
Residue:
223
Sequence:
MPWAVGRRWAWITLFLTIVAVLIQAVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSHGHSGRYWAEISDTIISGTFHQWREGTTKSEVYYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALSDTIFSTQDFLTLFYTLRAYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50006607
Synonyms:
CHEMBL3235465 | US9604926, Compound SN-79 | US9724435, SN-79
Type:
Small organic molecule
Emp. Form.:
C23H26FN3O3
Mol. Mass.:
411.4692
SMILES:
CC(=O)c1ccc2n(CCCCN3CCN(CC3)c3ccc(F)cc3)c(=O)oc2c1
Structure:
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