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TargetThrombin-activable fibrinolysis inhibitor (TAFIa)
LigandBDBM50226610
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1339183
IC50 450±n/a nM
Citation Brink, MDahlÚn, AOlsson, TPolla, MSvensson, T Design and synthesis of conformationally restricted inhibitors of active thrombin activatable fibrinolysis inhibitor (TAFIa). Bioorg Med Chem22:2261-8 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Thrombin-activable fibrinolysis inhibitor (TAFIa)
Name:Carboxypeptidase B2 isoform A
Synonyms:CPB2 | CPU | Carboxypeptidase B2 | Carboxypeptidase B2 isoform A | Carboxypeptidase U | Plasma carboxypeptidase B | TAFI | Thrombin-activable fibrinolysis inhibitor | pCPB
Type:Enzyme
Mol. Mass.:48432.74
Organism:Homo sapiens (Human)
Description:Q96IY4
Residue:423
Sequence:
MKLCSLAVLVPIVLFCEQHVFAFQSGQVLAALPRTSRQVQVLQNLTTTYEIVLWQPVTAD
LIVKKKQVHFFVNASDVDNVKAHLNVSGIPCSVLLADVEDLIQQQISNDTVSPRASASYY
EQYHSLNEIYSWIEFITERHPDMLTKIHIGSSFEKYPLYVLKVSGKEQAAKNAIWIDCGI
HAREWISPAFCLWFIGHITQFYGIIGQYTNLLRLVDFYVMPVVNVDGYDYSWKKNRMWRK
NRSFYANNHCIGTDLNRNFASKHWCEEGASSSSCSETYCGLYPESEPEVKAVASFLRRNI
NQIKAYISMHSYSQHIVFPYSYTRSKSKDHEELSLVASEAVRAIEKISKNTRYTHGHGSE
TLYLAPGGGDDWIYDLGIKYSFTIELRDTGTYGFLLPERYIKPTCREAFAAVSKIAWHVI
RNV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50226610
NameBDBM50226610
Synonyms:(2S)-5-AMINO-2-[(1-PROPYL-1H-IMIDAZOL-4-YL)METHYL]PENTANOIC ACID | (2S)-5-amino-2-[(1-n-propyl-1H-imidazol-4-yl)methyl]-pentanoic acid | (S)-5-amino-2-((1-propyl-1H-imidazol-4-yl)methyl)pentanoic acid | CHEMBL398110
TypeSmall organic molecule
Emp. Form.C12H21N3O2
Mol. Mass.239.314
SMILESCCCn1cnc(C[C@H](CCCN)C(O)=O)c1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a