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TargetDihydrofolate reductase
LigandBDBM50010230
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1341015
IC50 600±n/a nM
Citation Martinelli, JEChaykovsky, MKisliuk, RLGaumont, YGittelman, MC Methotrexate analogues. 12. Synthesis and biological properties of some aza homologues. J Med Chem22:869-74 (1979) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dihydrofolate reductase
Name:Dihydrofolate reductase
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:18437.08
Organism:Lactobacillus casei
Description:ChEMBL_1357878
Residue:163
Sequence:
MTAFLWAQDRDGLIGKDGHLPWHLPDDLHYFRAQTVGKIMVVGRRTYESFPKRPLPERTN
VVLTHQEDYQAQGAVVVHDVAAVFAYAKQHPDQELVIAGGAQIFTAFKDDVDTLLVTRLA
GSFEGDTKMIPLNWDDFTKVSSRTVEDTNPALTHTYEVWQKKA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50010230
NameBDBM50010230
Synonyms:CHEMBL3245586
TypeSmall organic molecule
Emp. Form.C21H25N9O5
Mol. Mass.483.4805
SMILESCOC(=O)C[C@H](NC(=O)Nc1ccc(cc1)N(C)Cc1cnc2nc(N)nc(N)c2n1)C(=O)OC |r|
Structure
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