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Target
Dihydrofolate reductase
Ligand
BDBM50010230
Substrate
n/a
Meas. Tech.
ChEMBL_1341015 (CHEMBL3254994)
IC50
600±n/a nM
Citation
 Martinelli, JE; Chaykovsky, M; Kisliuk, RL; Gaumont, Y; Gittelman, MC Methotrexate analogues. 12. Synthesis and biological properties of some aza homologues. J Med Chem 22:869-74 (1979) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
DYR_LACCA | dhfR | folA
Type:
PROTEIN
Mol. Mass.:
18437.08
Organism:
Lactobacillus casei
Description:
ChEMBL_1357878
Residue:
163
Sequence:
MTAFLWAQDRDGLIGKDGHLPWHLPDDLHYFRAQTVGKIMVVGRRTYESFPKRPLPERTNVVLTHQEDYQAQGAVVVHDVAAVFAYAKQHPDQELVIAGGAQIFTAFKDDVDTLLVTRLAGSFEGDTKMIPLNWDDFTKVSSRTVEDTNPALTHTYEVWQKKA
  
Inhibitor
Name:
BDBM50010230
Synonyms:
CHEMBL3245586
Type:
Small organic molecule
Emp. Form.:
C21H25N9O5
Mol. Mass.:
483.4805
SMILES:
COC(=O)C[C@H](NC(=O)Nc1ccc(cc1)N(C)Cc1cnc2nc(N)nc(N)c2n1)C(=O)OC |r|
Structure:
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