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TargetDNA gyrase subunit B
LigandBDBM50010338
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1353018
IC50 3.7±n/a nM
Citation Ahuja, VBasavarajappa, HP, SHBoriack-Sjodin, PAMcKinney, DGanguly, SKranthi, UGaonkar, SJena, LkGhorpade, SRGhosh, ABarde, SKale, MGKoushik, KKumar, CNManjunatha, MROgg, DPanduga, VRamya, VKReddy, JKumar, KNGiridhar, JRudrapatna, SSharma, STucker, JAVachaspati, PWaterson, Dde Sousa, SM Thiazolopyridine ureas as novel antitubercular agents acting through inhibition of DNA Gyrase B. Cell Chem Biol56:8834-48 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
DNA gyrase subunit B
Name:DNA gyrase subunit B
Synonyms:gyrB
Type:PROTEIN
Mol. Mass.:74505.25
Organism:Mycobacterium smegmatis
Description:ChEMBL_107961
Residue:675
Sequence:
MAAQKNNAPKEYGADSITILEGLEAVRKRPGMYIGSTGERGLHHLIWEVVDNAVDEAMAG
FATRVDVKIHADGSVEVRDDGRGIPVEMHATGMPTIDVVMTQLHAGGKFDGETYAVSGGL
HGVGVSVVNALSTRLEATVLRDGYEWFQYYDRSVPGKLKQGGETKETGTTIRFWADPEIF
ETTDYNFETVARRLQEMAFLNKGLTIELTDERVTAEEVVDDVVKDTAEAPKTADEKAAEA
TGPSKVKHRVFHYPGGLVDYVKHINRTKTPIQQSIIDFDGKGPGHEVEIAMQWNAGYSES
VHTFANTINTHEGGTHEEGFRAALTSVVNRYAKDKKLLKDKDPNLTGDDIREGLAAVISV
KVAEPQFEGQTKTKLGNTEVKSFVQKICNEQLQHWFEANPAEAKTVVNKAVSSAQARIAA
RKARELVRRKSATDIGGLPGKLADCRSTDPSKSELYVVEGDSAGGSAKSGRDSMFQAILP
LRGKIINVEKARIDRVLKNTEVQSIITALGTGIHDEFDISKLRYHKIVLMADADVDGQHI
STLLLTLLFRFMKPLVENGHIFLAQPPLYKLKWQRSEPEFAYSDRERDGLLEAGRAAGKK
INVDDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAAADELFSILMGEDVEARR
SFITRNAKDVRFLDV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50010338
NameBDBM50010338
Synonyms:CHEMBL3259858
TypeSmall organic molecule
Emp. Form.C21H26N6O4S
Mol. Mass.458.534
SMILESCCNC(=O)Nc1nc2cc(c(N[C@H]3CCOC3)nc2s1)-c1ccn(CCOC)c(=O)c1 |r|
Structure
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n/a